TY - JOUR AU - Jobim, Micheli Lamberti AU - Barbisan, Fernanda AU - Fortuna, Milena AU - Teixeira, Cibele Ferreira AU - Boligon, Aline Augusti AU - Ribeiro, Euler Esteves AU - Cruz, Ivana Beatrice Mânica da PY - 2019/06/28 Y2 - 2024/03/29 TI - Açai (Euterpe oleracea, Mart.), an Amazonian fruit has antitumor effects on prostate cancer cells JF - Archives in Biosciences & Health JA - Arch. Biosc. Health VL - 1 IS - 1 SE - Articles - Original research DO - 10.18593/abh.16966 UR - https://periodicos.unoesc.edu.br/abh/article/view/16966 SP - 61-76 AB - <p>Açai (<em>Euterpe oleracea, </em>Mart.) is fruit broadly consumed in the world. From its chemical matrix is possible that açai could has some cytotoxic effect against prostate cancer (PCa). To test this hypothesis using an <em>in vitro</em> PCa model DU145 cell. Additionally, potential synergism between açai and docetaxel (DO), a chemotherapic drug used to treat advanced PCa was also evaluated. Cells were exposed an açai hydro alcoholic extract at different concentrations (1 to 1000 μg/mL) and its effect on viability, apoptosis and cellular proliferation was determined by MTT assay, growth cell, clonogenic assays and cell cycle analysis by flow cytometry. Differential modulation of <em>Bcl-2 and BAX </em>genes was also determined by Pcr quantitative in real time (qRT-PCR) analysis. Açai at lower concentrations (1-10 μg/mL) presented significant cytotoxic and antiproliferative action against PCa cells decreasing frequency of S phase cycle. Probably, this effect was associated with its strong down-regulation of <em>Bcl-2</em> gene. However, açai did not contribute to improve Docetaxel effect´s on PCa cells. Açai’s PCa antitumor effects could be related to elevate concentrations of orientin plus vitexin, p-coumaric acid, apigenin and catechins present its chemical matrix, which are molecules with antitumor effect previously described in the literature.</p> ER -