@article{Jobim_Barbisan_Fortuna_Teixeira_Boligon_Ribeiro_Cruz_2019, title={Açai (Euterpe oleracea, Mart.), an Amazonian fruit has antitumor effects on prostate cancer cells}, volume={1}, url={https://periodicos.unoesc.edu.br/abh/article/view/16966}, DOI={10.18593/abh.16966}, abstractNote={<p>Açai (<em>Euterpe oleracea, </em>Mart.) is fruit broadly consumed in the world. From its chemical matrix is possible that açai could has some cytotoxic effect against prostate cancer (PCa). To test this hypothesis using an <em>in vitro</em> PCa model DU145 cell. Additionally, potential synergism between açai and docetaxel (DO), a chemotherapic drug used to treat advanced PCa was also evaluated. Cells were exposed an açai hydro alcoholic extract at different concentrations (1 to 1000 μg/mL) and its effect on viability, apoptosis and cellular proliferation was determined by MTT assay, growth cell, clonogenic assays and cell cycle analysis by flow cytometry. Differential modulation of <em>Bcl-2 and BAX </em>genes was also determined by Pcr quantitative in real time (qRT-PCR) analysis. Açai at lower concentrations (1-10 μg/mL) presented significant cytotoxic and antiproliferative action against PCa cells decreasing frequency of S phase cycle. Probably, this effect was associated with its strong down-regulation of <em>Bcl-2</em> gene. However, açai did not contribute to improve Docetaxel effect´s on PCa cells. Açai’s PCa antitumor effects could be related to elevate concentrations of orientin plus vitexin, p-coumaric acid, apigenin and catechins present its chemical matrix, which are molecules with antitumor effect previously described in the literature.</p>}, number={1}, journal={Archives in Biosciences & Health}, author={Jobim, Micheli Lamberti and Barbisan, Fernanda and Fortuna, Milena and Teixeira, Cibele Ferreira and Boligon, Aline Augusti and Ribeiro, Euler Esteves and Cruz, Ivana Beatrice Mânica da}, year={2019}, month={Jun.}, pages={61–76} }